GYNECOLOGIC CANCERS

Olaparib in combination with bevacizumab demonstrated a statistically significant and clinically meaningful improvement in progression-free survival as a frontline maintenance regimen compared with bevacizumab alone in women with advanced ovarian cancer, according to early results from the phase III PAOLA-1 trial.

Ovarian Cancer

Heavily Pretreated Recurrent Ovarian Cancer

Laura Dawson, MD, FRCPC, FASTRO, has been selected as the president-elect of the American Society for Radiation Oncology and will begin her term at the society’s 61st Annual Meeting, which is being held in Chicago, Illinois on September 15-18.

Ana Oaknin, MD, head of the Gynecologic Tumors Unit, Vall d’Hebron University Hospital, and principal investigator, Gynecological Malignancies Group, explains the rationale for analyzing anti–PD-1 monotherapy with dostarlimab in patients with microsatellite instability–high and microsatellite stable endometrial cancer. 

In the phase III PRIMA trial, niraparib demonstrated a benefit in progression-free survival compared with placebo when used as maintenance therapy following platinum-based chemotherapy for patients with ovarian cancer treated in the first line. The PFS benefit was found to be statistically significant, regardless of patients’ biomarker status, meeting the primary endpoint of the trial.