LUNG CANCER

A cohort of cancer centers was selected to serve as models for identifying key strategies for racial and ethnic minority group engagement in clinical trials. On the basis of several qualifying criteria, such as sustained accrual of minorities into clinical cancer research, an established minority population ≥10% in the overall catchment, an established clinical trial infrastructure, and a formal community outreach program, the investigators identified 8 cancer centers for participation.

In a case-based-style discussion, Tanios S. Bekaii-Saab, MD, and Wells Messersmith, MD, reviewed the treatment of patients with colorectal cancer whose tumors express rare gene mutations or molecular signatures, such as <em>NTRK</em> fusions.

<em>Targeted Oncology</em>&nbsp;spoke with experts in attendance at the 2019 ASCO Annual Meeting to review what they believed were some of the biggest takeaways from this year&#39;s presentation across the fields of lung cancer, breast cancer, GI cancers, genitourinary cancers, melanoma, and multiple myeloma.

Eric Harris, DO, hematologist/oncologist, Florida Cancer Specialists & Research Institute, gives Targeted Oncology an insiders perspective on the current state of community oncology in Florida and some ways the Florida Society of Clinical Oncology (FLASCO) aids in improving patient care by helping physicians.

Preliminary results from a phase II trial demonstrated promising activity for brigatinib in patients with non&ndash;small cell lung cancer with an&nbsp;<em>ALK&nbsp;</em>rearrangement who have progressed on treatment with another next-generation ALK tyrosine kinase inhibitor.

Alexander Drilon, MD, clinical director, Early Drug Development Service, and associate professor of the Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, discusses the data examining the role of entrectinib in patients with non&ndash;small cell lung cancer who are na&iuml;ve to treatment with a ROS1 tyrosine kinase inhibitor.

Two targeted therapies in development have demonstrated encouraging activity as potential treatments targeting hard-to-target driver alterations in lung cancer. During the 2019 ASCO Annual Meeting,&nbsp;Christine M. Lovly, MD, PhD, reviewed the early promising findings for TAK-788 for patients with&nbsp;non&ndash;small cell lung cancer harboring&nbsp;<em>EGFR</em> exon 20 insertions and for BLU-667 for patients with&nbsp;<em>RET&nbsp;</em>rearrangements.&nbsp;&nbsp;