Biomarker-Driven Lung Cancer
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July 28th 2018
By Silas Inman
Combinations with immunotherapy agents have surged ahead with new regimens showing great potential for the treatment of patients with lung cancer, Corey Langer, MD, said during a presentation at the <em>19th Annual </em>International Lung Cancer Congress (ILCC). Knowledge about a growing number of biomarkers are helping to guide treatment decisions with these combination options, he said, but the one standard of care has not yet been determined.
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Several biomarkers are beginning to emerge for immunotherapy in non–small cell lung cancer, and the collection of these markers, when used together, could further help to predict which patients are likely to respond to these therapies alone or in combination, according to a presentation by Giorgio Scagliotti, MD, PhD, at the <em>19th Annual</em> International Lung Cancer Congress.
Several novel agents are beginning to show promise for new targets in non–small cell lung cancer, especially <em>NRG1</em> and <em>LKB1, </em>and could be positioned to join already established standard-of-care therapies.
The primary endpoint of the phase III ALTA-1L trial has been met, as brigatinib was found to reduce the risk of disease progression or death versus crizotinib in adult patients with locally advanced or metastatic <em>ALK</em>-positive non–small cell lung cancer who had not received a prior ALK inhibitor, Takeda Pharmaceutical Company, the manufacturer of brigatinib, has announced.
According to findings from the phase III IMpower132 study, the addition of atezolizumab to pemetrexed and cisplatin or carboplatin reduced the risk of disease progression or death compared with chemotherapy alone in patients with advanced nonsquamous non–small cell lung cancer.
Alexander Drilon, MD, discusses the data currently available with targeting gene fusions, and shares insight into what is on the horizon in this area.
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