Opinion|Videos|March 14, 2025

Treatment Insights From RESPONSE: Ruxolitinib Therapy in Hydroxyurea-Resistant/Intolerant Disease

Author(s)Daniel Landau, MD

An expert discusses how the positive efficacy findings from the phase 3 RESPONSE trial, showing high rates of hematocrit control and spleen response with ruxolitinib vs standard therapy in hydroxyurea-resistant/intolerant polycythemia vera (PV), have enhanced the treatment approach for patients with inadequate response to hydroxyurea.

Episodes in this series

EP. 1 A 68-Year-Old Woman Diagnosed With Primary Myelofibrosis

EP. 1 A 68-Year-Old Woman Diagnosed With Primary Myelofibrosis

EP. 2 Molecular Profiling in MPNs: Enhancing Diagnostic Insights

EP. 2 Molecular Profiling in MPNs: Enhancing Diagnostic Insights

EP. 3 JAK V617F Monitoring and Risk Assessment Tools: Optimizing Treatment Decisions in MPN

EP. 3 JAK V617F Monitoring and Risk Assessment Tools: Optimizing Treatment Decisions in MPN

EP. 4 Treatment Insights From RESPONSE: Ruxolitinib Therapy in Hydroxyurea-Resistant/Intolerant Disease

EP. 4 Treatment Insights From RESPONSE: Ruxolitinib Therapy in Hydroxyurea-Resistant/Intolerant Disease

EP. 5 Advances in MPN Management: Insights From MANIFEST-2 and Beyond

EP. 5 Advances in MPN Management: Insights From MANIFEST-2 and Beyond

EP. 6 Quality of Life in MPNs: Patient-Centered Factors That Shape Treatment Approaches

EP. 6 Quality of Life in MPNs: Patient-Centered Factors That Shape Treatment Approaches

EP. 7 Academic Perspectives on the Evolving Treatment Landscape in MPNs

EP. 7 Academic Perspectives on the Evolving Treatment Landscape in MPNs

Video content above is prompted by the following:

The phase 3 RESPONSE trial findings showed high rates of hematocrit control and spleen response with ruxolitinib vs standard therapy in hydroxyurea-resistant/intolerant PV (Kiladjian et al. 2020 Lancet Haematol). How have these positive efficacy findings enhanced your treatment approach for patients with inadequate response to hydroxyurea?

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