Opinion|Videos|January 7, 2026

Sonrotoclax in R/R Mantle Cell Lymphoma After BTKi

Author(s)Marc S. Hoffmann, MD

New findings reveal promising advancements in treating relapsed mantle cell lymphoma with BCL-2 inhibitors and novel agents, enhancing patient outcomes.

Episodes in this series

1 panelist

EP. 1 Long-Term Data From SEQUOIA Study of Zanubrutinib in CLL

1 panelist

EP. 2 3-Year Data From SEQUOIA Arm D: Zanubrutinib Plus Venetoclax in Treatment-Naive, High-Risk CLL

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EP. 3 Long-Term Follow-Up Data From ALPINE: Zanubrutinib Vs Ibrutinib in R/R CLL.

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EP. 4 Sonrotoclax in R/R Mantle Cell Lymphoma After BTKi

Marc S. Hoffmann, MD, discusses initial results from a phase 1/2 study exploring the investigational next-generation BCL2 inhibitor sonrotoclax in patients with relapsed/refractory mantle cell lymphoma (MCL) previously treated with a BTK inhibitor. Hoffmann highlights response outcomes from single-agent sonrotoclax treatment, with particular emphasis on the durability of the responses. He also explains the next steps with sonrotoclax in MCL.

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