
Opinion|Videos|April 29, 2026
SEQUOIA Trial: Long-Term Safety Profile of Zanubrutinib in CLL
Author(s)Tanya Siddiqi, MD
High‑risk del17p CLL patients on single‑agent zanubrutinib show durable progression‑free survival, rivaling outcomes in standard‑risk groups.
Tanya Siddiqi, MD, highlights long-term safety outcomes with first-line zanubrutinib (Brukinsa) in patients with chronic lymphocytic leukemia in the phase 3 SEQUOIA trial. She explains that adverse events with zanubrutinib were manageable and notes that the risk of atrial fibrillation remains low with long-term use of the BTK inhibitor.
































