Opinion|Videos|December 19, 2025

PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

Author(s)Laura Huppert, MD

Episodes in this series

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 1 ASCENT-03 Results: Sacituzumab Govitecan in First-Line TNBC

EP. 2 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

EP. 2 PROs From ASCENT-04 Study of Sacituzumab Govitecan Plus Pembrolizumab in First-Line TNBC

EP. 3 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

EP. 3 ASCENT-03 and ASCENT-04 Sacituzumab Govitecan Safety Data Shared at SABCS 2025

Laura Huppert, MD, highlights patient-reported outcomes from the phase 3 ASCENT-04 trial which compared first-line treatment with the antibody-drug conjugate sacituzumab govitecan plus the PD-1 inhibitor pembrolizumab vs pembrolizumab plus chemotherapy in patients with PD-L1–positive advanced triple-negative breast cancer. Huppert discusses specific PROs and their impact on quality of life, along with the overall significance of PRO data in fully understanding patients’ experience with specific treatments.

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