Knowledge Gaps and Future Directions

The final segment highlights key challenges and opportunities in the evolving landscape of EGFR-mutant NSCLC management. Panelists identify gaps in real-world implementation, including unequal access to molecular testing, variability in practice patterns, and the need for improved management of resistanceresistance management. They discuss ongoing research focused on emerging agents, novel combinations, and strategies to enhance CNS penetration and overcome resistance mechanisms. The discussion concludes with optimism about how continued innovation, broader testing access, and collaborative clinical research will refine first-line and sequential treatment strategies.