Opinion|Videos|March 7, 2025

KarMMa-3 Highlights: Ide-Cel vs Standard Regimens in Triple-Class– Exposed RRMM

Author(s)Rafael Fonseca, MD, Binod Dhakal, MD, MS, Doris K. Hansen, MD

Panelists discuss how the KarMMa-3 trial demonstrated superior efficacy of idecabtagene vicleucel (ide-cel) chimeric antigen receptor T-cell therapy compared to standard treatment regimens in patients with heavily pretreated, triple-class–exposed relapsed/refractory multiple myeloma (RRMM).

Episodes in this series

4 experts are featured in this series.

EP. 1 Expert Insights: Navigating the Evolving Treatment Landscape in NDMM

4 experts are featured in this series.

EP. 2 Clinical Insights: Starting with a Patient Case 1: 74yo 74-Year-Old Patient With NDMM Transplant- Ineligible NDMM

4 experts are featured in this series.

EP. 3 Evaluating Guideline-Recommended Treatment Options for Transplant-Ineligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 4 Diving Deep Into the CEPHEUS Trial: Subcutaneous Dara-VRd vs VRd in Transplant-Ineligible or Transplant-Deferred NDMM

4 experts are featured in this series.

EP. 5 IMROZ Data Highlights and Clinical Insights Into Quadruplet CD38-Containing Regimens in Transplant-Ineligible NDMM

4 experts are featured in this series.

EP. 6 Patient Case 2: A 65-Year-Old Patient With Standard-Risk, Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 7 Selecting Among Guideline Recommended Treatment Options in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 8 PERSEUS Trial Highlights: Dara-VRd vs VRd in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 9 Clinical Perspectives: Question to Start Asking Is Who Not to Give Quadruplet CD38-Containing Regimens in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 10 Exploring Maintenance Strategies Post Autologous Transplant

4 experts are featured in this series.

EP. 11 Patient Case 4: A 58-Year-Old Woman With High-Risk MM Post HSCT With Progressive Disease—What Are Next Steps?

4 experts are featured in this series.

EP. 12 Patient Case 4: A 38-Year-Old Woman With Functional High-Risk MM With Progressive Disease at Day 60 Post ASCT—Next Treatment Approaches

4 experts are featured in this series.

EP. 13 Strategies to Overcome CAR T Roadblocks in the Real-World Practice Setting

4 experts are featured in this series.

EP. 14 CARTITUDE-4 Highlights: Cilta-Cel vs Standard of Care in R/R MM

4 experts are featured in this series.

EP. 15 CARTITUDE-4: Navigating Late CAR-T Toxicities

4 experts are featured in this series.

EP. 16 Patient Case 5: A 66-Year-Old Patient With R/R MM With Relapse Less Than 2 Years Post ASCT—Next Steps

4 experts are featured in this series.

EP. 17 KarMMa-3 Highlights: Ide-Cel vs Standard Regimens in Triple-Class– Exposed RRMM

4 experts are featured in this series.

EP. 18 KarMMa-3 Trial: Additional Insights From Ide-Cel in RRMM

4 experts are featured in this series.

EP. 19 Future Outlooks for CAR T in Early R/R Multiple Myeloma

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