Opinion|Videos|April 7, 2025

Current Practices and Initial Treatment Considerations for Patients With cGVHD

Author(s)Nelson Chao, MD, MBA

A panelist discusses how steroid therapy remains the cornerstone of acute graft-vs-host disease (GVHD) treatment, with treatment protocols typically starting with prednisone at doses ranging from 1 to 2 mg/kg/day depending on disease severity, though optimal dosing strategies continue to be refined through clinical research.

Episodes in this series

1 expert is featured in this series.

EP. 1 Clinical Case – A Patient With Steroid-Refractory cGVHD

1 expert is featured in this series.

EP. 2 Current Practices and Initial Treatment Considerations for Patients With cGVHD

1 expert is featured in this series.

EP. 3 Long-Term Outcomes of Ruxolitinib Therapy in Patients With cGVHD

1 expert is featured in this series.

EP. 4 Ruxolitinib Therapy for cGVHD: Insights on Patient and Safety Monitoring

1 expert is featured in this series.

EP. 5 The Treatment Landscape for cGVHD: From Current Practices to Evolving Therapies

1 expert is featured in this series.

EP. 6 Academic Perspectives and Key Considerations for Optimal Patient Care in cGVHD

Video content above is prompted by the following:

Please elaborate on steroid therapy for GVHD.
What are your thoughts on the prednisone dosing for this patient?
Are there any additional considerations to monitor and treat for (ie, supportive care)?
When do you consider other treatment modalities beyond steroid therapy?

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