Opinion|Videos|May 5, 2026

Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

Author(s)Joshua K. Sabari, MD

FDA‑approved zongertinib transforms HER2‑mutant NSCLC, delivering ~77% responses with less toxicity than chemo.

Episodes in this series

EP. 1 Background of Targeting HER2 in NSCLC

EP. 1 Background of Targeting HER2 in NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 2 Emerging Treatment Options for HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 3 Beamion LUNG‑1 Trial: Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 4 Depth and Durability of Response to Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 5 Safety and Tolerability of Zongertinib in HER2-Positive NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

EP. 6 Next-Generation Sequencing and HER2-Mutations in Metastatic NSCLC

Joshua K. Sabari, MD, describes the design and outcomes of the Beamion LUNG‑1 trial, which supported the FDA approvals of zongertinib in both treatment-naive and previously treated patients with HER2 mutation–positive non–small cell lung cancer. Along with dosing details, he highlights efficacy and safety outcomes across several patient cohorts in the trial.

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