LUNG CANCER

During separate virtual live events, David R. Gandara, MD, and Alexander Spira, MD, PhD, discussed the timing of durvalumab in non–small cell lung cancer from the PACIFIC trial with participating physicians.

An otherwise healthy 60-year-old woman, who has quit smoking for 8 years after 13 pack years, presented with a nonproductive cough. The patient was diagnosed with non–small cell lung cancer. Oncologists discuss the scenario during a Case-Based Roundtable event.

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, provide an overview of their major conclusions and clinical pearls for the treatment approach of EGFR Exon 20 Insertion+ NSCLC.

Experts review the toxicity of mobocertinib and further discuss the key findings from the EXCLAIM Trial.

The high prevalence of bone metastases in non–small cell lung cancer led 2 institutions to investigate how these metastases impact survival in patients treated with immune checkpoint inhibitors.

A 59-year-old White male presented with chest pain, cough, and dyspnea and an image-guided biopsy revealed poorly differentiated adenocarcinoma of the lung.

In an interview with Targeted Oncology™, Eric S. Nadler, MD, discusses IMpower133’s real-world implication and the effects immunotherapy has had on the ES-SCLC space.

A new cell therapy containing autologous tumor-infiltrating lymphocytes followed by nivolumab maintenance is both safe and clinically active in patients with metastatic non-small cell lung cancer.

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, review amivantamab and poziotinib as other treatment options for EGFR Exon 20 Insertion+ NSCLC.

An explanation of the EXCLAIM Trial and the mechanism of action, clinical development, and the overall clinical development program of mobocertinib.

Jared Weiss, MD, led a discussion about a 59-year-old patient with RET-fusion-positive non–small cell lung cancer during a Targeted Oncology Case-Based Roundtable event.

Treatment with amivantamab-vmjw in the phase 1 CHRYSALIS study has released anti-tumor activity in patients with non-small cell lung cancer harboring MET exon 14 skipping mutations treated with the agent.

Jorge Nieva, MD, discusses the results of the Impower010 study, which evaluated the efficacy of the checkpoint inhibitor atezolizumab after chemotherapy for lung cancer compared to best supportive care. 

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, review current treatments for EGFR Exon 20 Insertion+ NSCLC, their preferred treatments, and current clinical trials.

Experts review the demographics of patients who should be tested and how to discuss EGFR Exon 20 Insertion+ NSCLC with patients.

Molecular testing revealed RET-mutant non–small cell lung cancer in a 59-year-old patient. The case was a topic of discussion during a Case-Based Roundtable event led by Kartik Konduri, MD.

A discussion on how this variant of NSCLC differs from the (exon 19 and exon 21) EGFR mutations and the demographics of EGFR patients.

Joel Neal, MD, PhD, and Alexander I Spira, MD, PhD, FACP, discuss the recent identification of EGFR exon 20 insertion+ mNSCLC and how patients responded before the new drugs were introduced.

A significantly longer overall survival was achieved with the human IgG4 monoclonal antibody sintilimab in patients with locally advanced or metastatic nonsquamous non–small cell lung cancer treated in the phase 3 ORIENT-11 clinical trial.

Molecular testing practices and treatment decisions can vary for patients with non–small cell lung cancer. Cesar A. Perez, MD, and a group of other physicians discussed next steps in care for a patient with non–small cell lung cancer whose molecular test results revealed a RET mutation.

During a Targeted Oncology Case-Based Roundtable event, Harry Harper, MD, discussed treatment approaches for a 68-year-old patient with RET-mutated non–small cell lung cancer.

Patients with advanced non-small cell lung cancer treated with cemiplimab in combination with platinum-doublet chemotherapy saw an improvement in overall survival in comparison with patients who received chemotherapy alone, meeting the primary end point of the phase 3 EMPOWER-Lung 3 study.

In a Targeted Oncology Case-Based Roundtable event Edward S. Kim, MD, MBA, discussed new regimens for the treatment of non-small cell lung cancer.

The FDA has accepted the supplemental biologics license application submitted for atezolizumab as adjuvant treatment following surgery and platinum-based chemotherapy for people with non-small cell lung cancer whose tumors express PD-L1≥1%, as determined by an FDA-approved test and granted it priority review.

In an interview with Targeted Oncology™, Robert Coleman, MD, discussed the evolving treatment paradigm of lung cancer and the role of molecular testing now and in the future.