HCC
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January 25th 2020
By Wayne Kuznar
The addition of ipilimumab with the combination cabozantinib and nivolumab led to higher response rates, as well as progression-free survival and overall survival in patients with advanced hepatocellular carcinoma compared with the doublet combination alone, according to a presentation at the 2020 GI Cancers Symposium, held January 23-25, in San Francisco, California.
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The standard of care for some patients with intermediate-stage hepa­tocellular carcinoma may include lenvatinib if investigators further explore results from a proof-of-concept obser­vational study. The recommended treatment for intermediate-stage hepatocellular carcinoma, transarterial chemo­embolization, is unsuitable in patients with high-tumor-burden hepatocellular carcinoma, leaving a signif­icant unmet need in clinical practice for this patient subgroup.
The present and future benefits of telehealth in oncology can be observed through Tahoe For­est Cancer Center and its affiliation with the UC Davis Cancer Center, use of other remote clinics, and participation in virtual tumor boards. Even though there are roadblocks to telehealth reaching more locations and more patients, the potential benefit warrants the time needed to get over those hurdles.
In an interview with Targeted Oncology, Wasif M. Saif, MD, discussed the current treatment landscape and recent expansions in hepatocellular carcinoma that are providing him with hope for the field.
A phase Ib/2 clinical trial has been initiated to assess the anti-tumor activity of FGFR4 targeted therapy fisogatinib plus the anti–PD-L1 monoclonal antibody CS1001 for the treatment of patients with locally advanced or metastatic hepatocellular carcinoma.
The FDA granted approval to countless treatments across cancer types throughout 2019 until the end of the year, with a final approval on December 31<sup>st </sup>for the first BRCA targeted therapy in pancreatic cancer. Following the excitement for a new year of further advances, Targeted Oncology followers on Twitter shared their thoughts on some of the most impactful FDA approvals in 2019.
In an interview with Targeted Oncology, Thomas Yau, MD, discussed the findings from the phase III CheckMate trial evaluating nivolumab in patients with advanced hepatocellular carcinoma compared with standard-of-care sorafenib. He highlighted the next steps for the trial following these data, which were presented at the 2019 European Society of Medical Oncology Congress.
María Varela, MD, PhD, discusses the findings from a real-life analysis to confirm the benefit of regorafenib as treatment of patients with hepatocellular carcinoma who have progressed on prior sorafenib. Regorafenib was approved by the FDA for second-line treatment in this patient population based on data from the phase III RESORCE trial.
In November 2019, the FDA approved a number of treatments, including acalabrutinib for the treatment of chronic lymphocytic leukemia and small lymphocytic leukemia, as well as zanubrutinib for the treatment of mantle cell lymphoma. A biosimilar for pegfilgrastim was also approved under indications.
In patients whose solid<strong> </strong>tumors harbor a mutation in <em>KRAS </em>G12C, therapy with MRTX849 has produced promising responses and acceptable toxicity across 3 tumors types, according to data presented at the 2019 American Association for Cancer Research–National Cancer Institute–European Organization for Research and Treatment of Cancer International Conference on Molecular Targets and Cancer Therapeutics.
What is the ideal first-line<strong> </strong>therapy for nonresectable, non– transplant eligible, liver-only hepatocellular carcinoma? In a debate at the 2019 Gastrointestinal Oncology Conference, Mark Yarchoan, MD, had the unenviable task of convincing the audience that systemic therapy was the way to go.