Colorectal Cancer
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October 3rd 2019
By Wayne Kuznar
Using a measure known as the growth modulation index, patients with TRK fusion–positive cancers who were treated with larotrectinib had a clinically meaningful improvement in progression-free survival compared with the time to progression on their prior treatment, an analysis of patients enrolled in 1 of 3 clinical trials has found.
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In an interview with Targeted Oncology, Stacey Stein, MD, discussed what attendees can expect to learn about at the 2019 ISGIO Annual Conference in terms of the treatment landscape for CRC. She also highlighted some of the recent advancements that physicians treating CRC should be aware of heading into this meeting.
Certain patients with BRAF non-V600-mutant, RAS-dependent metastatic colorectal cancer may be sensitive to anti-EGFR therapy, according to the results of a a multicenter pooled analysis recently published in Clinical Cancer Research. The analysis suggested that those with RAS<em>-</em>dependent tumors were more likely to respond to anti-EGFR therapy than those with RAS-independent tumors.
The use of more aggressive frontline chemotherapy regimens plus biologics for the treatment of patients with meta-static colorectal cancer may be warranted based on mutational status, tumor sidedness, treatment goals, prognosis, and patient disposition, according to a presentation by Axel Grothey, MD, at the 14th Annual New Orleans Summer Cancer Meeting, held July 19 to 21, 2019, in Louisiana.
Heinz-Josef Lenz, MD, discusses the significance of the latest updates in the CheckMate 142 trial exploring an immunotherapy treatment combination in patients with metastatic colorectal cancer whose tumors are microsatellite instability–high or mismatch repair deficient.
John L. Marshall, MD, spoke with a group of physicians during a Targeted Oncology live case-based peer perspectives discussion on the different classes of agents available to treat patients with gastrointestinal cancers.
In an interview with <em>Targeted Oncology</em> following his presentation at the <em>3rd Annual</em> Congress on Oncology & Pathology hosted by PER®, Gulam A. Manji, MD, discussed the emergence of new therapies for targeting mutations in patients with colon cancer.
At a recent Targeted Oncology live case-based peer perspectives event, Kanwal P. S. Raghav, MBBS, MD, presented a case scenario of a patient with colorectal cancer who has already gone through first- and second-line treatments. Raghav explained the treatment considerations he would make with similar patients in the clinic and the treatment options available to this patient with CRC in this setting.
Overall survival was not improved with the use of lefitolimod as a maintenance therapy compared with local standard-of-care therapy in patients with metastatic colorectal cancer, according to early findings from the pivotal phase III IMPALA trial. The median OS was 22.0 months with lefitolimod compared with 21.9 months with standard of care, which failed to meet the primary endpoint of the trial.
Howard S. Hochester, MD, discusses findings from the pooled safety analysis of TAS-102 in previously treated patients with colorectal cancer and gastric/gastroesophageal junction adenocarcinoma.
A phase III trial is being initiated to evaluate the combination of regorafenib and nivolumab in comparison with regorafenib alone in patients with microsatellite stable metastatic colorectal cancer.
A dose-escalation strategy for giving regorafenib improved the frequency of adverse events while still demonstrating similar efficacy to a standard-dose strategy in patients with metastatic colorectal cancer.
