Greg Kennelty

In an interview with Targeted Oncology, Edward Kim, MD, discussed the FDA-approved immunotherapies nivolumab and pembrolizumab along with potential combinations, biomarkers, and ongoing research.

New technology and improvements in administration techniques could make the utilization of stereotactic body radiation therapy easier and more plausible for patients with pancreatic cancer, according to Joseph Michael Herman, MD.

A subgroup analysis of the phase III SAR-3007 trial demonstrating the efficacy of trabectedin (Yondelis) in patients with advanced uterine leiomyosarcoma bodes well for the malignancy's armamentarium, according to Martee L. Hensley, MD.

Expanding on the efficacy shown in numerous single-group studies, a phase II study published in The Lancet Oncology showed lenalidomide significantly increased progression free survivalin patients with relapsed or refractory mantle cell lymphoma.

Investigators hope a duo of just-opened phase III studies will support expanding the FDA approval of olaparib (Lynparza) in ovarian cancer, according to Ursula A. Matulonis, MD.

Researchers are now working on refining the use of PARP inhibitors in ovarian cancer by gaining a greater understanding of mechanisms of resistance and exploring combination and sequencing possibilities. For expert insight on these topics, Targeted Oncology sat down with Shannon Westin, MD.

Ghassan Abou-Alfa, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center, discusses the significance of a recent trial and how the findings can impact the treatment paradigm of HCC.

The combination of nab-paclitaxel (Abraxane) and gemcitabine is steadily gaining in popularity among oncologists in the treatment armamentarium for pancreatic adenocarcinoma, according to Fadi Braiteh, MD.

The protein NOD-like receptor X1 (NLRX1) could be a potential biomarker to predict response for treatments in patients with colorectal cancer (CRC), according to a study published in Cell Reports.

Frontline treatment with CPX-351 (Vyxeos) significantly boosted overall survival (OS) for older patients with high-risk, secondary acute myeloid leukemia (AML).

A recent publication from The Cancer Genome Atlas (TCGA) has opened the door wide for a slew of new, non-BRAF targeted agents in melanoma, according to Jason J. Luke, MD, FACP.

With the proven efficacy of both BREF/MEK inhibitors and immunotherapies, Jeffrey S. Weber, MD, PhD, discusses which to use first in patients with melanoma.

With updated data further proving its efficacy, Jonathan R. Strosberg, MD, says Lu-Dotatate 177 could be an excellent addition to oncologists' armamentarium against midgut neuroendocrine tumors (NETs).

Advances in kidney cancer deal much more in surgery, rather than treatment options, according to Alexander Kutikov, MD, FACS.

The PD-L1 inhibitor atezolizumab (MPDL3280A) showed promising antitumor activity in patients with inoperable locally advanced or metastatic urothelial carcinoma whose disease had progressed after previous platinum-based chemotherapy.

Immune checkpoint inhibitors have shown promising findings for patients with advanced bladder cancer, with data from phase II studies submitted to the FDA for consideration. The next question facing oncologists is how to optimally utilize these agents, according to James L. Gulley, MD, PhD.

Vitamin D deficiency could lead to a quickly growing primary tumor and a hastened development of metastases for patients with breast cancer, according to researchers at Stanford University School of Medicine.

Eribulin combination strategies are based on scientific evidence, rather than empirical evidence, and could provide a new chemotherapy-based backbone in the treatment paradigm of the malignancy, according to Christopher Twelves, MD.

In an interview, Frakes discusses a recent study and the impact these data have on follow-up frequency and the overall treatment paradigm for patients with OPSCC.

In an interview with Targeted Oncology, Abbruzzese discussed the underlying disparity between high-volume centers and community medical centers for the treatment of pancreatic cancer.

The combination of ziv-aflibercept and capecitabine demonstrated an acceptable safety profile and encouraging clinical efficacy for patients with metastatic colorectal cancer, according to findings from the ongoing phase II X-TRAP trial.

Neoadjuvant therapy has become increasingly plausible for patients with advanced pancreatic cancer, as the quantity and quality of approved therapies continue to increase, according to Colin Weekes, MD, PhD.

While still in its early stages, integrative genomic testing could be the future for personalizing therapy for patients with castration-resistant prostate cancer (CRPC), according to Tomasz M. Beer, MD, FACP.

Despite its initial running start, the continuing development of immunotherapies in the field of non-small cell lung cancer (NSCLC) won't be slowing down anytime soon, according to Naiyer Rizvi, MD.

Barbara Burtness, MD, discusses the explosion of immunotherapies on the horizon for patients with metastatic head and neck cancer.

Anaplastic thyroid cancer is an extremely aggressive form of cancer that cannot be cured by surgery and has a median survival of about 6 months. The malignancy normally occurs in patients over the age of 60, and there is not a standard of care, according to John A. Copland III, PhD, professor, Cancer Biology, Mayo Clinic.

A new treatment delivery method is being explored that combines real-time imaging with convection-enhanced delivery of chemotherapy for patients with high-grade gliomas, according to the lead investigator of early phase research exploring the approach, Nicholas A. Butowski, MD.

Preclinical research conducted on tumor samples and mouse models showed that FGL2 is secreted by glioblastoma, which causes the upregulation of immune suppression mechanisms. Additionally, in these early studies, an anti

To gain further insight into TAS-102 and regorafenib, Targeted Oncology spoke with Tanios Bekaii-Saab, MD, on how he utilizes currently available data to provide optimal care for patients with chemorefractory CRC.

The understanding that medulloblastoma is comprised of 4 distinct molecular subtypes of disease, each representing a unique opportunity for new drug development, has set the groundwork for a wave of advances in the treatment of pediatric brain cancer, according to Matthias A. Karajannis, MD.