Opinion|Videos|July 29, 2024

Classification Changes Impacting the Treatment of LR-MDS

Author(s)Guillermo Garcia-Manero, MD

A medical oncology specialist discusses how recent data and improvements in genomic profiling are changing the classification of lower-risk MDS.

Episodes in this series

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 1 Overview of Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 2 Standard-of-Care Treatment for Patients with LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 3 Erythroid Maturating Agents (EMAs) for Frontline or Second-Line Treatment of Anemia in LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 4 COMMANDS Trial: Study Design, Patient Population, and Results

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 5 Classification Changes Impacting the Treatment of LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 6 Dose Escalation of Luspatercept on Trial and Real-World Data

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 7 Adverse Events with EMAs: Luspatercept

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 8 Current Approach for Treating Anemia in LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 9 Future Treatment for Anemia of LR-MDS

Guillermo Garcia-Manero, MD, an expert on MDS

EP. 10 Clinical Pearls for Community Oncologist Treating LR-MDS

Video content above is prompted by the following:

Two recent data presentations have reported on the impact of baseline mutational burden on clinical outcomes for ESAs and luspatercept.
- Please discuss the efficacy of ESAs in patients with very low vs. moderate low to very high IPSS-M risk groups.
- Please discuss the clinical outcomes of luspatercept vs. epoetin alfa from the COMMANDS trial based on IPSS-M risk groups (low, moderate low, moderate high and high) and baseline mutational burden.

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