|Articles|December 8, 2013

Arming an Anti-CD38 Antibody With Interferon in Myeloma

James R. Berenson, MD, discusses a study presented at the 2013 American Society of Hematology (ASH) Meeting that looked at arming an anti-CD38, myeloma-targeting antibody with interferon.

Clinical Pearls

James R. Berenson, MD, Medical and Scientific Director, Institute for Myeloma & Bone Cancer Research, discusses a study presented at the 2013 American Society of Hematology (ASH) Meeting that looked at arming an anti-CD38, myeloma-targeting antibody with interferon.

Interferon was used to treat myeloma (maintain remissions) in the 1980s and 1990s
When paired with interferon, this anti-CD38 agent can enhance tumor-specific activity 10,000x compared with native interferon
This pairing cured multiple tumors in mice
It remains unknown if this pairing will have effects on immune and other cells in the human body

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