Opinion|Videos|December 25, 2024

Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

Author(s)Guillermo Garcia-Manero, MD, David Swoboda, MD

Panelists discuss how the final efficacy and safety analysis from the COMMANDS trial (Della Porta et al, Lancet 2024) highlights the role of luspatercept in first-line treatment for lower-risk myelodysplastic syndrome (LR-MDS), with particular consideration of ribosomal stress (RS) status and serum erythropoietin (EPO) levels, emphasizing its potential to improve hemoglobin levels and transfusion independence in this patient population.

Episodes in this series

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 1 Introduction to the Discussion of Frontline Treatment for Newly Diagnosed Lower-Risk Myelodysplastic Syndromes.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 2 Defining LR-MDS: Initial Patient Presentation and Updates in MDS Risk.

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 3 Frontline Treatment Options for LR-MDS Beyond ESAs

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 4 Overview of Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 5 Academic Perspectives: Patient Populations for Frontline Luspatercept in LR-MDS

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 6 Emerging Insights and Perspectives From COMMANDS (Luspatercept in LR-MDS)

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 7 The Impact of Mutational Burden on Responses With Frontline Luspatercept in LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 8 Factors that Influence Treatment Choices and Goals in Frontline LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 9 Dosing Strategies for Frontline luspatercept in LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 10 Novel Updates in Second-line Therapies for LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 11 Sequencing Therapies in LR-MDS

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

EP. 12 Academic Perspectives for LR-MDS Treatment in the Community

Discuss final efficacy and safety analysis from the COMMANDS trial (Della Porta et al, Lancet 2024).
1. Elaborate on the role of luspatercept in first-line treatment of patients with LR-MDS
2. Consider RS status and serum EPO level.
3. What are your thoughts on the efficacy and potential benefits of luspatercept in this patient population?

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