|Videos|June 9, 2014

Research into the Monoclonal Antibody GC33 for HCC

Ghassan K. Abou-Alfa, MD, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, discusses two analyses of GC33 for the treatment of hepatocellular carcinoma (HCC).

Clinical Pearls

Ghassan K. Abou-Alfa, MD, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, discusses two analyses of GC33 for the treatment of hepatocellular carcinoma (HCC).

GC33 is a humanized monoclonal antibody against GPC3 that is frequently expressed in HCC.
In aphase Ib dose escalation study, GC33 was looked at in combination with sorafenib. Though GC33 showed questionable tolerability, the agent will be looked at with a biomarker component in a future trial.
Aphase II triallooking at GC33 in previously treated patients with HCC was also negative.

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