Acute Myeloid Leukemia with Myelodysplastic-Related Cytogenetics

Case: A 68-Year-Old Man Withde novoAML

History and Physical:

• A 68-year-old man presented with significant fatigue and shortness of breath on exertion; reports low-grade fever for the past few days.
• PMH: mild hypertension, hypercholesterolemia, both medically managed; no history of malignancy

Laboratory work-up:

• WBC, 2.6 X 10⁹/L
• ANC, 1.2 X 10⁹/L
• Hb, 9.4 X 10⁹/L
• Hct, 32%
• RBC, 3.3 X 10⁹/L
• MCV, 121 fL
• PLT, 95 X 10⁹/L

Bone marrow biopsy:65% blasts

Peripheral blood smear;70% blasts

FISH;del(5q), del (20q)

Diagnosis;AML, myelodysplasia-related cytogenetic abnormalities