|Articles|October 1, 2014

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

Author(s)Emmanuel S. Antonarakis, MBBCh

Emmanuel S. Antonarakis, MBBCh, assistant professor, Johns Hopkins Medicine, discusses the results of a trial that examined AR-V7 and resistance to enzalutamide and abiraterone in patients with prostate cancer.

Clinical Pearls

The study showed that about 39% (12 of 31) of patients in the enzalutamide arm had AR-V7 detected in their circulating tumor cells.
Every patient taking enzalutamide that had AR-V7 did not obtain a PSA response to enzalutamide.
In the abiraterone arm, 19% (6 of 31) were found to have AR-V7.
Similarly, all of these patients demonstrated resistance to abiraterone. â€‹

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