Dr. Hammers discusses initial impressions of the case presentation, comparing it to typical advanced RCC, and reviewing risk factors.
A 59-Year-Old African American Woman with Clear Cell, Renal Cell Carcinoma (ccRCC)
Dr. Hammers provides a perspective on the appropriateness of initial pembrolizumab + lenvatinib therapy based on guidelines.
Dr. Hammers summarizes key efficacy findings from the CLEAR study of pembrolizumab + lenvatinib vs sunitinib.
Dr. Hammers discusses recent efficacy and safety data updates from CHECKMATE-214, KEYNOTE-426, and CHECKMATE-9ER trials.
Dr. Hammers explains factors involved in decision-making between immunotherapy-based treatment options.
Dr. Hammers shares his experience with high-grade AEs in IO-TKI treated patients and how toxicities are mitigated/managed.
Dr. Hammers outlines his thought process around TKI/ICI dose modifications vs discontinuations with toxicity and discusses toxicity management recommendations.
Provide perspective on quality-of-life observations with different IO-TKI regimens and supporting evidence.
Dr. Hammers discusses future management for advanced RCC, unmet needs, and emerging data being monitored.